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Pfizer, Inc. Senior Associate Scientist, Protein Biology .and. Crystallization in Minneapolis, Minnesota

Company Overview A career at Pfizer offers opportunity, ownership and impact. All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have opportunities to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives. Research unit overview Pfizer- Boulder Research and Development, located in Boulder, Colorado USA, is a fully integrated drug discovery unit focusing on research and development of targeted small molecule therapeutic agents to treat patients afflicted with cancer. Summary We are seeking a protein biologist to join the Structural Biology group at Pfizer- Boulder Research and Development Unit. This individual will work closely with our protein biology experts to express, purify, characterize, and crystallize a variety of challenging proteins for use in both structural and mechanistic studies. Responsibilities Perform E. coli growth and recombinant protein expressions at liter-scale Purify recombinant proteins from E. coli or eukaryotic host cells Conduct protein crystallization trials and optimization Biochemical and/or biophysical characterization of proteins Process and document experimental data Contribute to written and oral presentations related to research findings Basic Qualifications Bachelor of Science with 3+ years' or Master of Science with 0-2 years' research experience after graduation Experience in recombinant protein expressions in E. coli Experience in protein purification at mg-level yields with minimum supervision Familiar with AKTA purifier system and standard analytical techniques associated with assessing protein purification process Strong organizational, problem-solving, and written/oral communication skills Preferred Qualifications Experience in protein crystallization resulted in diffracting crystals Able to collect X-ray diffraction data from protein crystals Experience in or familiar with biochemical or biophysical assays on protein functions Physical/Mental Requirements Able to lift 50lb objects with dimensions 12 inches in height and 26 inches in width Able to visualize microscopic objects under microscopes Non-Standard Work Schedule, Environment Requirements Able to adhere to safe work practices and perform lab works with appropriate personal protection equipment such as but not limited to safety goggles, facial mask, gloves, lab coat/ protective gowning, and closed toe shoes Able to work at flexible hours occasionally when performing time-sensitive experiments Other Job Details Eligible for Employee Referral Bonus #LI-PFE Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact y

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